编码针对乙型肝炎病毒S抗原的单克隆抗体重链和轻链的cDNA的克隆与鉴定
Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody specific for the S antigen of hepatitis B virus.
作者信息
Ryu C J, Jin B R, Chung H K, Han M H, Hong H J
机构信息
Genetic Engineering Research Institute, KIST, Taejon, South Korea.
出版信息
Gene. 1994 Jul 8;144(2):313-4. doi: 10.1016/0378-1119(94)90398-0.
PMID:8039721
Abstract
The nucleotide (nt) sequences encoding the variable regions of the heavy and light chains of a murine monoclonal antibody (mAb) have been determined. The mAb recognizes a disulfide-bond-dependent conformational epitope on the hepatitis B virus surface antigen. The sequence analyses revealed that the variable regions of the heavy and light chains are members of mouse heavy-chain subgroup II(A) and kappa light-chain subgroup III, respectively.
摘要
已确定了一种鼠单克隆抗体（mAb）重链和轻链可变区的核苷酸（nt）序列。该单克隆抗体识别乙型肝炎病毒表面抗原上一个依赖二硫键的构象表位。序列分析表明，重链和轻链的可变区分别属于小鼠重链II（A）亚组和κ轻链III亚组。
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