Los G, Muggia F M
University of California, UCSD Cancer Center, La Jolla.
Hematol Oncol Clin North Am. 1994 Apr;8(2):411-29.
It has become clear that multiple mechanisms of cellular resistance to platinum compounds exist; however, the knowledge that platinum resistance can not only be explained by processes such as reduced drug accumulation, and increased detoxification, has shifted the attention of researchers to more molecular mechanisms. The introduction of new techniques, such as the PCR technique for example, has opened the possibility to monitor genes involved in antitumor responses and may provide molecular information on the emergency of resistance.
很明显，细胞对铂类化合物存在多种耐药机制；然而，铂耐药不仅可以用药物积累减少和解毒增加等过程来解释，这一认识已将研究人员的注意力转移到更多分子机制上。新技术的引入，例如PCR技术，为监测参与抗肿瘤反应的基因提供了可能性，并可能提供有关耐药出现的分子信息。
