Nogita T, Wong T Y, Hidano A, Mihm M C, Kawashima M
Department of Dermatology, Tokyo Women's Medical College, Japan.
J Am Acad Dermatol. 1994 Aug;31(2 Pt 1):235-40.
Thirty-two cases are described of a relatively rare form of benign connective tissue proliferation characterized by ectopic fatty tissue in the dermis. The lesions usually appear as large, solitary, slow-growing, pedunculated to dome-shaped, skin-colored nodules or plaques showing predilection for the buttock and upper thigh. Other areas involved include the back, shoulder, knee, neck, and ear. Twenty patients were women and 12 were men, 19 to 78 years of age (mean, 46.9 years). The size of the lesions ranged from 4 to 69 mm (mean, 49 mm). Histologically, the lesions were characterized by the presence of mature adipose tissue infiltrating around the periadnexal adventitial dermis and between adnexal structures and admixing with dense stromal collagen. Marked deposition of mucopolysaccharides was noted in the majority of the lesions. Clinical follow-up in all 32 patients showed no evidence of recurrence. Because of their distinctive clinicopathologic features, we prefer to designate these lesions as solitary, pedunculated lipofibroma. In addition, seven of the patients had diabetes mellitus, suggesting a possible relation between the two conditions.
本文描述了32例相对罕见的良性结缔组织增生病例，其特征为真皮内异位脂肪组织。病变通常表现为大的、孤立的、生长缓慢的、带蒂至圆顶状的、肤色结节或斑块，好发于臀部和大腿上部。其他受累部位包括背部、肩部、膝盖、颈部和耳部。20例为女性，12例为男性，年龄在19至78岁之间（平均46.9岁）。病变大小从4至69毫米不等（平均49毫米）。组织学上，病变的特征是成熟脂肪组织浸润于附属器周围的真皮外膜和附属器结构之间，并与致密的间质胶原混合。大多数病变中可见明显的粘多糖沉积。对所有32例患者的临床随访均未发现复发迹象。由于其独特的临床病理特征，我们倾向于将这些病变命名为孤立性带蒂脂肪纤维瘤。此外，7例患者患有糖尿病，提示这两种情况之间可能存在关联。
