Mehregan D A, Su W P, Kurtin P J
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
J Cutan Pathol. 1994 Apr;21(2):110-7. doi: 10.1111/j.1600-0560.1994.tb00244.x.
Recently, T-cell lymphoma localized to the subcutaneous tissue has been reported. We report the clinical, histologic, immunohistochemical, and molecular genetic findings in 6 patients who we believe had this peculiar T-cell lymphoma with its unique morphologic and clinical features. All patients presented with deep-seated nodules, most frequently on the extremities, and with systemic complaints of low-grade fever, fatigue, myalgias, and weight loss. In all cases, the neoplastic lymphocytic infiltrate was confined to the subcutaneous tissue, predominantly in a lobular pattern. Hemorrhage, necrosis, and rare erythrophagocytosis were also seen. Immunohistochemical staining was predominantly T-cell reactive (CD43, CD3, and CD45RO). Clonal rearrangements of the beta and gamma chains of the T-cell antigen receptor genes were found in 1 case. Three of the 6 patients died within 22 months of the diagnosis of lymphoma. We believe that subcutaneous T-cell lymphomas are a distinctive group of peripheral T-cell lymphomas with unusual clinical and morphologic features and that they should be distinguished from other types of lymphoma.
最近，有皮下组织局限性T细胞淋巴瘤的报道。我们报告了6例患者的临床、组织学、免疫组化及分子遗传学结果，我们认为这些患者患有这种具有独特形态学和临床特征的特殊T细胞淋巴瘤。所有患者均表现为深部结节，最常见于四肢，并伴有低热、疲劳、肌痛和体重减轻等全身症状。在所有病例中，肿瘤性淋巴细胞浸润局限于皮下组织，主要呈小叶状分布。还可见出血、坏死及罕见的噬红细胞现象。免疫组化染色主要呈T细胞反应性（CD43、CD3和CD45RO）。1例患者发现T细胞抗原受体基因的β和γ链存在克隆性重排。6例患者中有3例在淋巴瘤诊断后22个月内死亡。我们认为皮下T细胞淋巴瘤是一组具有不寻常临床和形态学特征的独特外周T细胞淋巴瘤，应与其他类型的淋巴瘤相鉴别。
