Clementz B A, Iacono W G, Beiser M
Department of Psychology, University of California, San Diego, La Jolla 92093-0109.
J Abnorm Psychol. 1994 May;103(2):400-3.
We evaluated the handedness of 58 schizophrenia patients and 54 of their relatives, 23 patients with major depression with psychosis and 24 of their relatives, 36 patients with bipolar psychosis and 33 of their relatives, and 119 nonpsychiatric subjects and 42 of their relatives. Computerized tomography measures were also available for a subset of the psychotic patients. The schizophrenia patients were significantly more left-handed than any of the other groups, and increased sinistrality was also associated with larger lateral ventricle to brain area ratios. The relatives of the schizophrenia patients did not significantly differ on handedness from either the relatives of the affective psychosis patients or the nonpsychiatric subjects. Our findings do not support the notion that left-handedness in schizophrenia is genetically influenced. More research with larger family member data sets is warranted to further explore this possibility.
我们评估了58名精神分裂症患者及其54名亲属、23名伴有精神病性症状的重度抑郁症患者及其24名亲属、36名双相精神病患者及其33名亲属，以及119名非精神科受试者及其42名亲属的用手习惯。部分精神病患者还进行了计算机断层扫描测量。精神分裂症患者比其他任何组的左利手程度都显著更高，而且左利手程度增加还与侧脑室与脑区的比例增大有关。精神分裂症患者的亲属在用手习惯上与情感性精神病患者的亲属或非精神科受试者的亲属没有显著差异。我们的研究结果不支持精神分裂症中的左利手受遗传影响这一观点。有必要对更多家庭成员数据集进行进一步研究，以进一步探索这种可能性。
