Cohanim M, Yendt E R
Johns Hopkins Med J. 1975 Mar;136(3):137-41.
Urine zinc (Zn) excretion was significantly higher in 338 male patients with renal calculi than in 21 normal male subjects, but there was no significant difference between 102 female patients with renal calculi and 15 normal female subjects. In 33 patients with renal calculi urinary Zn was less than 50% of the mean normal value; in these patients there is a possibility that lower urine Zn excretion contributes to the formation of renal calculi. Hydrochlorothiazide produced a striking and sustained increase in urinary Zn excretion, which might contribute to the efficacy of this drug in the prevention of calcific renal stones. Serum Zn levels remained normal in the majority of subjects on long term thiazide therapy, but the occasional finding of subnormal levels suggests that long term thiazide therapy carries with it the hazard of Zn deficiency.
338例男性肾结石患者的尿锌（Zn）排泄量显著高于21名正常男性受试者，但102例女性肾结石患者与15名正常女性受试者之间无显著差异。33例肾结石患者的尿锌低于正常平均值的50%；在这些患者中，尿锌排泄降低有可能促成肾结石的形成。氢氯噻嗪使尿锌排泄显著且持续增加，这可能有助于该药物预防钙化性肾结石的疗效。大多数长期接受噻嗪类药物治疗的受试者血清锌水平保持正常，但偶尔发现低于正常水平表明长期噻嗪类药物治疗存在锌缺乏的风险。
