Emel'ianova L P, Saf'ianova V M, Bomba L K, Zinovina O V
Med Parazitol (Mosk). 1993 May-Jun(3):3-6.
Thirty-four strains of seven Old World Leishmania species were analyzed for 12 enzymes. The findings indicate isoenzymatic profile geographic changeability of some Leishmania species: Tested L. major, L. tropica, and L. infantum strains from Africa, Middle East, and Central Asia were found to be represented by individual zymodemes differing between themselves by 3-5 enzymes. Many identical zymodemes could induce in some cases skin, in other visceral symptoms in the carriers. Great isoenzymatic affinity between L. tropica and L. donovani sensu lato strains was detected. The nature of intraspecies Leishmania zymodeme variability being virtually not studied at present, the authors emphasize the usefulness of clone studies.
对来自七个旧大陆利什曼原虫物种的34个菌株进行了12种酶的分析。研究结果表明，某些利什曼原虫物种的同工酶谱具有地理变异性：来自非洲、中东和中亚的受试硕大利什曼原虫、热带利什曼原虫和婴儿利什曼原虫菌株由个体酶型代表，这些酶型之间有3-5种酶不同。在某些情况下，许多相同的酶型可在携带者中引发皮肤症状，而在其他情况下则引发内脏症状。检测到热带利什曼原虫和杜氏利什曼原虫复合种菌株之间存在很大的同工酶亲和力。由于目前几乎没有研究种内利什曼原虫酶型变异的本质，作者强调了克隆研究的有用性。
