猫奥迪括约肌内源性神经元中烟酰胺腺嘌呤二核苷酸磷酸黄递酶（NADPH-d）活性的分布及形态学特征

Distribution and morphological features of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) activity in intrinsic neurons of the Oddi sphincter of the cat.

作者信息

Fehér E, Montagnese C

机构信息

First Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Neurosci Lett. 1994 Mar 28;170(1):114-6. doi: 10.1016/0304-3940(94)90252-6.

DOI:10.1016/0304-3940(94)90252-6

PMID:8041484

Abstract

To clarify the role of nitric oxide (NO) in the sphincter of Oddi, we histochemically investigated the distribution of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), a marker for NO synthase, in the cat. NADPH-diaphorase activity was localized in two neuronal subtypes: large neurons with many dendrites and smaller with one process. Most of the nerve cell bodies (99%) in the wall of the sphincter of Oddi showed strong activity for this enzyme. The nerve fibers with NADPH-d activity were observed in all layers, chiefly in the muscle layers. These results suggest that NO may play a very important role in the neuronal regulation of sphincter of Oddi.

摘要

为阐明一氧化氮（NO）在奥迪括约肌中的作用，我们采用组织化学方法研究了烟酰胺腺嘌呤二核苷酸磷酸黄递酶（NADPH-d，一种一氧化氮合酶的标志物）在猫体内的分布。NADPH-黄递酶活性定位于两种神经元亚型：具有许多树突的大神经元和具有一个突起的较小神经元。奥迪括约肌壁中的大多数神经细胞体（99%）对该酶表现出强活性。在所有层中均观察到具有NADPH-d活性的神经纤维，主要位于肌肉层。这些结果表明，NO可能在奥迪括约肌的神经调节中发挥非常重要的作用。