Handa V L, Bachus K E, Johnston W W, Robboy S J, Hammond C B
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
Obstet Gynecol. 1994 Aug;84(2):215-8.
To test the hypothesis tha a very-low-dose regimen of vaginal estrogen would provide effective relief from atrophic vaginitis without endometrial proliferation.
Twenty postmenopausal women with symptoms, signs, and cytologic evidence of atrophic vaginitis were enrolled. Each subject was treated with 0.3 mg of conjugated estrogens, administered vaginally 3 nights per week for 6 months. We examined the following outcomes: symptoms, vaginal cellular (cytologic) maturity, endometrial histology, sonographic evaluation of endometrial thickness, Doppler measures of uterine artery blood flow, and serum levels of estrone and estradiol. Pre- and post-treatment data were compared for each subject.
Satisfactory relief of symptoms occurred in 19 of 20 cases. Vaginal cellular maturation improved significantly with therapy (P < .01). There were no significant changes in endometrial thickness, uterine artery blood flow, or serum estrogen levels. Endometrial proliferation was observed in one case.
Relief from atrophic vaginitis can be achieved with 0.3 mg of conjugated estrogens administered vaginally three times per week. Endometrial proliferation may occur at this low dose, albeit rarely.
检验极低剂量阴道雌激素方案可有效缓解萎缩性阴道炎且无子宫内膜增生这一假设。
招募20名有萎缩性阴道炎症状、体征及细胞学证据的绝经后女性。每位受试者每周3个晚上阴道给予0.3mg结合雌激素，持续6个月。我们检查了以下结果：症状、阴道细胞（细胞学）成熟度、子宫内膜组织学、子宫内膜厚度的超声评估、子宫动脉血流的多普勒测量以及雌酮和雌二醇的血清水平。对每位受试者的治疗前后数据进行比较。
20例中有19例症状得到满意缓解。治疗后阴道细胞成熟度显著改善（P < 0.01）。子宫内膜厚度、子宫动脉血流或血清雌激素水平无显著变化。1例观察到子宫内膜增生。
每周3次阴道给予0.3mg结合雌激素可缓解萎缩性阴道炎。此低剂量虽极少发生，但可能出现子宫内膜增生。
