JAK1和JAK2酪氨酸激酶与白细胞介素2受体β链和γ链的物理关联。
Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.
作者信息
Tanaka N, Asao H, Ohbo K, Ishii N, Takeshita T, Nakamura M, Sasaki H, Sugamura K
机构信息
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7271-5. doi: 10.1073/pnas.91.15.7271.
The functional interleukin 2 (IL-2) receptors contain the beta and gamma chains which are necessary for the transduction of cell growth signals. Monoclonal antibodies specific for the beta chain and gamma chain coimmunoprecipitated JAK1 and 114-kDa JAK2 tyrosine kinases, respectively. Tyrosine phosphorylation of JAK1 and JAK2 was induced upon IL-2 stimulation, and IL-2 activated the JAK2 kinase. These results demonstrate that the JAK1 and JAK2 tyrosine kinases are physically associated with the beta chain and gamma chain, respectively, and suggest that regulation of the kinases may be linked to IL-2-induced signal transduction.
功能性白细胞介素2（IL-2）受体包含β链和γ链，它们是细胞生长信号转导所必需的。针对β链和γ链的单克隆抗体分别共免疫沉淀了JAK1和114 kDa的JAK2酪氨酸激酶。IL-2刺激后诱导了JAK1和JAK2的酪氨酸磷酸化，并且IL-2激活了JAK2激酶。这些结果表明，JAK1和JAK2酪氨酸激酶分别与β链和γ链物理相关，并提示激酶的调节可能与IL-2诱导的信号转导有关。
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