Brach B B, Blackard W, Rothschild H
South Med J. 1975 Feb;68(2):202-5. doi: 10.1097/00007611-197502000-00019.
A review of 2,647 consecutive deaths over a 19-month period at a large metropolitan hospital revealed 27 cases (1%) to be coded as metabolic acidosis. In ten of these deaths, a presumptive diagnosis of lactic acidosis could be made. Eight of the ten were diabetic, and all eight were treated with phenformin at the time of their last admission. Although phenformin could not be incriminated as the sole cause of lactic acidosis in these cases, a contributory role of the drug seems probable. The indiscriminate use of phenformin in diabetic patients should be discouraged and the contraindications to the use of phenformin should be stressed.
对一家大型都市医院19个月内连续发生的2647例死亡病例进行回顾发现，有27例（1%）被编码为代谢性酸中毒。在这些死亡病例中，有10例可作出乳酸性酸中毒的推定诊断。这10例中有8例是糖尿病患者，且所有8例在最后一次入院时均接受苯乙双胍治疗。虽然在这些病例中不能将苯乙双胍认定为乳酸性酸中毒的唯一原因，但该药物似乎可能起到了促成作用。应劝阻在糖尿病患者中滥用苯乙双胍，并应强调使用苯乙双胍的禁忌证。
