Caux F, Lebbe C, Thomine E, Benyahia B, Flageul B, Joly P, Rybojad M, Morel P
Service de Dermatologie, Hôpital Saint-Louis, Paris, France.
Br J Dermatol. 1994 Jul;131(1):102-7. doi: 10.1111/j.1365-2133.1994.tb08465.x.
We report a patient with erythema gyratum repens (EGR), in whom a bronchial carcinoma was found. Direct immunofluorescence revealed granular deposits of immunoglobulins at the basement membrane zone (BMZ) in the skin, and in the lung tumour. Direct immunoelectron microscopy showed that the immune deposits were localized just beneath the lamina densa. Indirect immunofluorescence revealed circulating anti-BMZ antibodies. Immunohistochemical staining, using anti-transforming growth factor-beta, anti-epidermal growth factor receptor, anti-vimentin and anti-alpha-actin, was found to be more intense in the lesional skin and the lung tumour than in normal tissues. Possible mechanisms in the pathogenesis of EGR are discussed.
我们报告了一名患有回状红斑（EGR）的患者，在该患者中发现了支气管癌。直接免疫荧光显示皮肤和肺肿瘤的基底膜带（BMZ）有免疫球蛋白颗粒沉积。直接免疫电子显微镜显示免疫沉积物位于致密层下方。间接免疫荧光显示循环抗BMZ抗体。使用抗转化生长因子-β、抗表皮生长因子受体、抗波形蛋白和抗α-肌动蛋白进行免疫组织化学染色，结果显示病变皮肤和肺肿瘤中的染色比正常组织中更强烈。本文讨论了EGR发病机制中的可能机制。
