Setterfield J, Shirlaw P J, Lazarova Z, Bryant B M, Bhogal B S, Harman K, Challacombe S J, Black M M
St John's Institute of Dermatology, St Thomas' Hospital (GKT), London SE1 7EH, UK. j.setterfield2umds.ac.uk
Br J Dermatol. 1999 Jul;141(1):127-31. doi: 10.1046/j.1365-2133.1999.02933.x.
We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.
我们报告了一名39岁患有抗表皮剥脱性瘢痕性类天疱疮（CP）并伴有非小细胞肺癌的女性。就诊时，黏膜病变对联合全身免疫抑制剂治疗反应甚微。在诊断为非小细胞肺癌并随后使用吉西他滨（一种二线化疗药物）治疗后，观察到肿瘤肿块和黏膜水疱均显著缩小。随后，转移性疾病与复发性口腔糜烂相关。我们认为该患者代表了首例报道的副肿瘤性CP病例。
