Facon T, Caulier M T, Wattel E, Jouet J P, Bauters F, Fenaux P
Service des Maladies du Sang, C.H.U. Lille, France.
Br J Haematol. 1994 Mar;86(3):678-80. doi: 10.1111/j.1365-2141.1994.tb04810.x.
Forty-two patients with ITP were randomly allocated to vinblastine slow infusion or bolus injection. 16/21 patients (76%) receiving slow infusion of vinblastine and 14/21 patients (67%) receiving a bolus injection of vinblastine had a response. There was no superiority of slow infusions of vinblastine over intravenous bolus injections, either when recently diagnosed and chronic ITP were analysed together or separately. In our opinion, intravenous bolus injections of vinblastine might be preferred, because they are easier to perform and have a better local tolerance.
42例免疫性血小板减少症（ITP）患者被随机分配接受长春碱缓慢输注或大剂量注射。接受长春碱缓慢输注的21例患者中有16例（76%）有反应，接受长春碱大剂量注射的21例患者中有14例（67%）有反应。无论是将新诊断的ITP和慢性ITP一起分析还是分开分析，长春碱缓慢输注并不优于静脉大剂量注射。我们认为，长春碱静脉大剂量注射可能更可取，因为其操作更容易且局部耐受性更好。
