García-Pascual I J, Sánchez-Yagüe J, Rodríguez Hernández M C, Paniagua Gómez-Alvárez R
Sección de Planificación Familiar y Fertilidad, Centro Médico San José de Tiabaya, Arequipa, Perú.
An Med Interna. 1994 Apr;11(4):177-80.
The present study proved that desmopressin (DDAVP) (1 microgram DDAVP/12 h/5 días) does not affect ovary, testis and adrenal development in immature Wistar rats (17 days old), because the DDAVP does not modify the weight of the aforementioned organs as compared with the control group. Nevertheless, the male adults Wistar rats (80 days old) showed lower serum testosterone concentrations than the control group, after injection of 4 micrograms/day (2 micrograms/12 h) or 8 micrograms/day (4 micrograms/12 h) of DDAVP during a 5 days period time. Moreover, paradoxical significant lower concentrations of serum testosterone were found in 4 micrograms DDAVP/day-treated rats than in 8 micrograms DDAVP/day-treated ones. The former also showed a decreased number of spermatozoa as compared with the latter and with the control group. The percentage of mobile spermatozoa was lower in rats treated with both concentrations of DDAVP as compared with the control group. Therefore, desmopressin does not delay gonadal and adrenal growth in immature rats, but, at low doses, it affects the testicular function and the mobility of the spermatozoa in male adult rats.
本研究证明，去氨加压素（DDAVP）（1微克DDAVP/12小时/5天）对未成熟Wistar大鼠（17日龄）的卵巢、睾丸和肾上腺发育没有影响，因为与对照组相比，DDAVP并未改变上述器官的重量。然而，在5天的时间里，每天注射4微克（2微克/12小时）或8微克（4微克/12小时）DDAVP后，成年雄性Wistar大鼠（80日龄）的血清睾酮浓度低于对照组。此外，发现每天接受4微克DDAVP治疗的大鼠血清睾酮浓度显著低于每天接受8微克DDAVP治疗的大鼠。与后者及对照组相比，前者的精子数量也有所减少。与对照组相比，两种浓度DDAVP治疗的大鼠中活动精子的百分比均较低。因此，去氨加压素不会延迟未成熟大鼠的性腺和肾上腺生长，但在低剂量时，它会影响成年雄性大鼠的睾丸功能和精子活力。
