[急性胰腺炎家兔血清因子作为实验性糖尿病中胰岛B细胞再生刺激物的研究]
[Serum factors in rabbits with acute pancreatitis as stimulators of regeneration of pancreatic islet B-cells in experimental diabetes].
作者信息
Zharkov V P, Iarygin V N, Dolzhikov A A
出版信息
Biull Eksp Biol Med. 1993 May;115(5):525-7.
PMID:8043844
Abstract
The experiment reveals the stimulating effect of pancreatic rabbits' serum on the reparative regeneration of pancreatic islets' B-cells of rabbits with alloxan diabetes. Serum, got 12 hours after mechanical pancreatic gland trauma proves to be most effective. The maximum rise of mitotic activity is in 24 hours after 3 daily injections of serum. In the experiment with the decrease of the level of proliferation of B-cells compensation of insulinary function by acinoinsulary transformation prevails.
摘要
实验揭示了胰腺兔血清对四氧嘧啶糖尿病兔胰岛B细胞修复性再生的刺激作用。机械性胰腺损伤12小时后获得的血清被证明是最有效的。在每日注射血清3次后的24小时，有丝分裂活性达到最高值。在实验中，随着B细胞增殖水平的降低，腺泡胰岛转化对胰岛素功能的代偿占主导地位。
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