Graber C D, Patrick C C, Galphin R L
Chest. 1975 Apr;67(4):408-10. doi: 10.1378/chest.67.4.408.
Light chain proteinuria was found in 9 of 17 tuberculosis patients treated with rifampin. Concomitant assay of cellular mediated immunity in these patients using skin test antigen and a lymphokine in vitro test provided results that were different. Response to Varidase skin test antigen was negative for all eight tuberculosis patients tested, but there occurred a hyper-responsiveness of the lymphocytes of these eight patients to phytomitogen (PHA-P). as well as of those of seven other tuberculous patients. This last finding may be related to time of testing and/or endogenous serum binding of rifampin which could have inhibited mitogen activity for the lymphocyte.
在17例接受利福平治疗的结核病患者中，有9例出现轻链蛋白尿。对这些患者同时使用皮肤试验抗原和体外淋巴细胞因子试验检测细胞介导免疫，结果有所不同。所有8例接受检测的结核病患者对瓦里idase皮肤试验抗原的反应均为阴性，但这8例患者的淋巴细胞对植物血凝素（PHA - P）以及其他7例结核病患者的淋巴细胞出现了高反应性。最后这一发现可能与检测时间和/或利福平的内源性血清结合有关，利福平可能抑制了淋巴细胞的有丝分裂原活性。
