Christlieb A R, Assal J P, Katsilambros N, Williams G H, Kozak G P, Suzuki T
Diabetes. 1975 Feb;24(2):190-3. doi: 10.2337/diab.24.2.190.
The renin-angiotensin-aldosterone system was evaluated in two types of uncontrolled diabetes: a) diabetic ketoacidosis, and b) nonketotic hyperglycemia. In thirteen patients with ketoacidosis, mean plasma renin activity (PRA) was 58 plus or minus 12 (S.E.M.) ng. per milliliter per hour and in four patients, plasma aldosterone was 82 plus or minus 17 ng. per 100 ml. Corresponding values for upright salt-depleted subjects were 13 plus or minus 2 and 62 plus or minus 8. In eleven diabetics with nonketotic hyperglycemia (mean glucose 318 plus or minus 19 mg. per cent), mean blood volume was 4,660 ml. and PRA 2.1 plus or minus .7. After control of the diabetes (mean glucose 129 plus or minus 13) blood volume was 4,553 ml. and PRA 3.3 plus or minus 1 (NS). The results suggest that: 1) diabetic ketoacidosis is a state of severe secondary aldosteronism, 2) no significant change in blood volume or PRA occurs during short periods of hyperglycemia, and 3) insulin is not necessary for renin release.
在两种类型的未控制糖尿病中评估了肾素 - 血管紧张素 - 醛固酮系统：a）糖尿病酮症酸中毒，以及b）非酮症高血糖症。在13例酮症酸中毒患者中，平均血浆肾素活性（PRA）为每小时每毫升58±12（标准误）纳克，在4例患者中，血浆醛固酮为每100毫升82±17纳克。直立性缺盐受试者的相应值为13±2和62±8。在11例非酮症高血糖症糖尿病患者（平均血糖318±19毫克％）中，平均血容量为4660毫升，PRA为2.1±0.7。糖尿病得到控制后（平均血糖129±13），血容量为4553毫升，PRA为3.3±1（无显著性差异）。结果表明：1）糖尿病酮症酸中毒是一种严重的继发性醛固酮增多症状态，2）在短时间高血糖期间血容量或PRA无显著变化，3）肾素释放不需要胰岛素。
