Lipkin P H, Goldstein I J, Adesman A R
Department of Pediatrics, Schneider Children's Hospital, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY.
Arch Pediatr Adolesc Med. 1994 Aug;148(8):859-61. doi: 10.1001/archpedi.1994.02170080089017.
To determine the incidence of tics or dyskinesias (T/D) and examine associated clinical factors in children treated with stimulant medications for attention-deficit hyperactivity disorder.
Cross-sectional analysis of a clinic cohort with chart review.
Hospital-based clinical service within a division of developmental and behavioral pediatrics.
One hundred twenty-two children with attention-deficit hyperactivity disorder treated with stimulant medication. All children currently or recently treated were included.
None.
Determinations were made of medication used, medication dosage, presence or absence of T/D, time of T/D onset, and history and family history of T/D. Incidence of T/D was 9.0% of children or 8.2% of medication trials. One child (0.8%) had development of Tourette's syndrome. Age, medication, dosage, history of tics, or family history of tics was not related to onset of T/D.
Approximately 9% of children with attention-deficit hyperactivity disorder treated with stimulant medication had development of T/D, predominantly transient in nature, with less than 1% having development of chronic tics or Tourette's syndrome. Personal or family tic history, medication selection, or dosage was not related to onset of T/D.
确定使用兴奋剂药物治疗注意缺陷多动障碍的儿童中抽动或运动障碍（T/D）的发生率，并检查相关临床因素。
对一个临床队列进行横断面分析并查阅病历。
发育与行为儿科学科内的医院临床服务部门。
122名使用兴奋剂药物治疗的注意缺陷多动障碍儿童。纳入所有目前正在接受治疗或近期接受过治疗的儿童。
无。
确定所使用的药物、药物剂量、是否存在T/D、T/D发作时间以及T/D的个人史和家族史。T/D的发生率在儿童中为9.0%，在药物试验中为8.2%。一名儿童（0.8%）发展为抽动秽语综合征。年龄、药物、剂量、抽动史或抽动家族史与T/D的发作无关。
使用兴奋剂药物治疗的注意缺陷多动障碍儿童中约9%出现了T/D，主要为短暂性，不到1%发展为慢性抽动或抽动秽语综合征。个人或家族抽动史、药物选择或剂量与T/D的发作无关。
