Grace P A
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Br J Surg. 1994 May;81(5):637-47. doi: 10.1002/bjs.1800810504.
Ischaemia-reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production, and the role of neutrophils and endothelial factors in ischaemia-reperfusion. Finally, several mechanisms that limit ischaemia-reperfusion injury are discussed and a number of novel therapies presented.
缺血再灌注损伤是外科实践中经常遇到的复杂现象。这种损伤的后果是局部和远处组织破坏，有时甚至导致死亡。其中涉及几种不同的过程。本文综述讨论了这种损伤的病理学、自由基产生的机制以及中性粒细胞和内皮因子在缺血再灌注中的作用。最后，讨论了一些限制缺血再灌注损伤的机制，并介绍了一些新的治疗方法。
