Wei L, Wang H Y, Zhang Y K
Institute of Renal Disease, Beijing Medical University.
Zhonghua Bing Li Xue Za Zhi. 1994 Feb;23(1):7-9.
A quantitative analysis of the components of glomerular extracellular matrix (ECM) was performed with the immunoperoxidase method (ABC method) and the computer imaging analysis system. The results demonstrate that with the development of mesangial proliferative glomerulonephritis (MsPGN), normal components of glomerular ECM (type IV collagen, laminin, fibronectin) increased markedly. In addition, interstitial collagen (type III collagen) appeared in the expanded mesangial matrix of moderate MsPGN and increased in severe MsPGN, suggesting that MsPGN is linked to the accumulation of ECM, not only the normal components, but also the interstitial collagen.
采用免疫过氧化物酶法（ABC法）和计算机图像分析系统对肾小球细胞外基质（ECM）成分进行定量分析。结果表明，随着系膜增生性肾小球肾炎（MsPGN）的发展，肾小球ECM的正常成分（IV型胶原、层粘连蛋白、纤连蛋白）显著增加。此外，间质胶原（III型胶原）出现在中度MsPGN扩张的系膜基质中，并在重度MsPGN中增加，提示MsPGN不仅与正常成分的ECM积聚有关，还与间质胶原的积聚有关。
