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委内瑞拉马脑炎病毒(VEEV):毒株分化及毒力标志物的确定

Venezuelan equine encephalomyelitis virus (VEEV):strain differentiation and specification of virulence markers.

作者信息

Walder R, Bradish C J

出版信息

J Gen Virol. 1975 Mar;26(3):265-75. doi: 10.1099/0022-1317-26-3-265.

DOI:10.1099/0022-1317-26-3-265
PMID:804536
Abstract

Fourteen strains of VEEV of diverse origin and antigenicity were classified into five virulence categories according to their efficiency of infection and nature of response in mice. Mice of ages up to 30 days represented distinct levels of responsiveness and were suitable for the differentiation of VEEV strains of highest to lowest virulence. Stepwise changes with age of the susceptibility or responsiveness of mice appeared to determined the type of response as predominantly lethal (D), dual or intermediate (DP) or protective (P).

摘要

根据14株不同来源和抗原性的委内瑞拉马脑炎病毒(VEEV)在小鼠体内的感染效率和反应性质,将它们分为五个毒力类别。30日龄以下的小鼠表现出不同程度的反应性,适用于区分毒力从高到低的VEEV毒株。小鼠易感性或反应性随年龄的逐步变化似乎决定了主要为致死性(D)、双重或中间性(DP)或保护性(P)的反应类型。

相似文献

1
Venezuelan equine encephalomyelitis virus (VEEV):strain differentiation and specification of virulence markers.委内瑞拉马脑炎病毒(VEEV):毒株分化及毒力标志物的确定
J Gen Virol. 1975 Mar;26(3):265-75. doi: 10.1099/0022-1317-26-3-265.
2
A multisystem approach for development and evaluation of inactivated vaccines for Venezuelan equine encephalitis virus (VEEV).一种用于开发和评估委内瑞拉马脑炎病毒(VEEV)灭活疫苗的多系统方法。
J Virol Methods. 2010 Feb;163(2):424-32. doi: 10.1016/j.jviromet.2009.11.006. Epub 2009 Nov 10.
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Effect of back passage of Venezuelan equine encephalomyelitis TC-83 vaccine virus on clinical, virologic, and immune responses in horses.委内瑞拉马脑炎TC-83疫苗病毒的反向传播对马的临床、病毒学和免疫反应的影响。
J Am Vet Med Assoc. 1972 Oct 1;161(7):824-31.
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Multi-factorial specification of virus-host interactions: studies with strains of Venezuelan equine encephalomyelitis virus in mice.病毒-宿主相互作用的多因素特异性:在小鼠中对委内瑞拉马脑炎病毒株的研究
J Gen Virol. 1979 Aug;44(2):373-82. doi: 10.1099/0022-1317-44-2-373.
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Vaccinia virus recombinants encoding the truncated structural gene region of Venezuelan equine encephalitis virus (VEEV) give solid protection against peripheral challenge but only partial protection against airborne challenge with virulent VEEV.编码委内瑞拉马脑炎病毒(VEEV)截短结构基因区域的痘苗病毒重组体可对周围感染提供可靠保护,但对强毒VEEV经空气传播的感染仅提供部分保护。
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[The immunity generated in white rats vaccinated with strains of the Venezuelan equine encephalomyelitis virus].
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Protection of mice by equine herpesvirus type 1 based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodies.在缺乏中和抗体的情况下,基于1型马疱疹病毒的实验性疫苗对小鼠的致死性委内瑞拉马脑炎病毒感染的保护作用。
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Responses of guinea pigs to infections with strains of Venezuelan encephalitis virus, and correlations with equine virulence.豚鼠对委内瑞拉脑炎病毒毒株感染的反应及其与马的毒力的相关性。
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Am J Trop Med Hyg. 1976 May;25(3):494-9. doi: 10.4269/ajtmh.1976.25.494.

引用本文的文献

1
Virion polypeptide heterogeneity among virulent and avirulent strains of eastern equine encephalitis (EEE) virus.
Arch Virol. 1981;68(3-4):229-37. doi: 10.1007/BF01314576.
2
Replication of alphaviruses in cultures of donkey monocytes.
Arch Virol. 1986;87(3-4):163-71. doi: 10.1007/BF01315296.
3
Kinetics of heat inactivation of Venezuelan equine encephalomyelitis virus.委内瑞拉马脑炎病毒的热灭活动力学
Arch Virol. 1976;51(4):307-17. doi: 10.1007/BF01317934.