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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Crawshaw L I, Stitt J T

J Physiol. 1975 Jan;244(1):197-206. doi: 10.1113/jphysiol.1975.sp010791.

Prostaglandins E1 (PGE1) was injected into the preoptic/anterior hypothalamic (PO/AH) area of the squirrel monkey. 2. Increases in rectal temperature (Tre) produced by PGE1 injections of 20 ng to 500 ng were dose-dependent. 3. When ambient temperature (Ta) was below the thermoneutral zone, increases in Tre were produced entirely by increases in metabolic rate. With Ta at the upper end of the thermoneutral zone, increases in Tre were produced by vasoconstriction in addition to lesser increases in metabolic rate. 4. During sessions of behavioural temperature regulation, PGE1 injections were followed by the selection of a higher Ta, increased skin temperature and subsequent increases in Tre. 5. PGE1 injections produce dose-dependent increases in Tre which are similar regardless of ambient temperature or whether behavioural or autonomic means are utilized to raise the heat content of the body.

将前列腺素E1（PGE1）注入松鼠猴的视前区/下丘脑前部（PO/AH）区域。2. 注射20纳克至500纳克PGE1所引起的直肠温度（Tre）升高呈剂量依赖性。3. 当环境温度（Ta）低于热中性区时，Tre的升高完全由代谢率的增加引起。当Ta处于热中性区上限时，Tre的升高除了代谢率有较小增加外，还由血管收缩引起。4. 在行为性体温调节期间，注射PGE1后会选择更高的Ta，皮肤温度升高，随后Tre升高。5. 注射PGE1会使Tre呈剂量依赖性升高，无论环境温度如何，也无论采用行为方式还是自主方式来提高身体的热量含量，情况都是如此。

Crawshaw L I, Stitt J T

J Physiol. 1975 Jan;244(1):197-206. doi: 10.1113/jphysiol.1975.sp010791.

Prostaglandins E1 (PGE1) was injected into the preoptic/anterior hypothalamic (PO/AH) area of the squirrel monkey. 2. Increases in rectal temperature (Tre) produced by PGE1 injections of 20 ng to 500 ng were dose-dependent. 3. When ambient temperature (Ta) was below the thermoneutral zone, increases in Tre were produced entirely by increases in metabolic rate. With Ta at the upper end of the thermoneutral zone, increases in Tre were produced by vasoconstriction in addition to lesser increases in metabolic rate. 4. During sessions of behavioural temperature regulation, PGE1 injections were followed by the selection of a higher Ta, increased skin temperature and subsequent increases in Tre. 5. PGE1 injections produce dose-dependent increases in Tre which are similar regardless of ambient temperature or whether behavioural or autonomic means are utilized to raise the heat content of the body.

将前列腺素E1（PGE1）注入松鼠猴的视前区/下丘脑前部（PO/AH）区域。2. 注射20纳克至500纳克PGE1所引起的直肠温度（Tre）升高呈剂量依赖性。3. 当环境温度（Ta）低于热中性区时，Tre的升高完全由代谢率的增加引起。当Ta处于热中性区上限时，Tre的升高除了代谢率有较小增加外，还由血管收缩引起。4. 在行为性体温调节期间，注射PGE1后会选择更高的Ta，皮肤温度升高，随后Tre升高。5. 注射PGE1会使Tre呈剂量依赖性升高，无论环境温度如何，也无论采用行为方式还是自主方式来提高身体的热量含量，情况都是如此。