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酒精与冠状动脉疾病

Alcohol and coronary artery disease.

作者信息

Ahlawat S K, Siwach S B

机构信息

Department of Medicine, Medical College, Rohtak, India.

出版信息

Int J Cardiol. 1994 Apr;44(2):157-62. doi: 10.1016/0167-5273(94)90020-5.

Abstract

Alcohol affects the heart and circulation in several ways. Chronic alcohol consumption can be associated with a variety of cardiovascular disorders, ranging from hypertension and stroke to heart failure and sudden death. At the same time an inverse correlation has been found between moderate drinking and incidence of coronary artery disease, perhaps due to its favourable effects on lipoprotein levels. Reports on acute effects of alcohol on coronary circulation, which may be of great significance in patients with pre-existing heart disease, have been contradictory. However, clinical studies have demonstrated an adverse effect of acute alcohol intake in low to moderate doses on coronary supply-demand relation in patients with angina pectoris. Considering the overall health hazard of alcohol consumption, a recommendation that patients increase their alcohol intake or that they start to drink if they do not already would probably be unjustifiable.

摘要

酒精通过多种方式影响心脏和血液循环。长期饮酒可能与多种心血管疾病相关,从高血压、中风到心力衰竭和猝死不等。与此同时,人们发现适度饮酒与冠状动脉疾病的发病率呈负相关,这可能是由于其对脂蛋白水平有有利影响。关于酒精对冠状动脉循环的急性影响的报道相互矛盾,而这对已有心脏病的患者可能具有重要意义。然而,临床研究表明,低至中等剂量的急性酒精摄入对心绞痛患者的冠状动脉供需关系有不利影响。考虑到饮酒对整体健康的危害,建议患者增加饮酒量或建议不饮酒者开始饮酒可能是不合理的。

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