Wong C K, Leung K N, Fung K P, Pang P K, Choy Y M
Department of Biochemistry, Chinese University of Hong Kong, Shatin, New Territories.
Int J Immunopharmacol. 1994 Apr;16(4):271-7. doi: 10.1016/0192-0561(94)90001-9.
Tumor necrosis factor (TNF) could be induced in the serum of ICR mice bearing Ehrlich ascites tumor (EAT) cells by the i.v. administration of antitumor fractions (PH-I A, PH-I B, PH-I C, PH-I Ca, PH-I Cb) separated from the roots of Pseudostellaria heterophylla. TNF could also be detected in the ascitic fluid of EAT-bearing mice 2 h after i.v. injection with PH-I C, PH-I Ca or PH-I Cb. The proliferation of EAT cells was found to be significantly suppressed after the administration of these fractions. Our results suggest that the antitumor activity of P. heterophylla may be related, at least in part, to its capacity to induce TNF production in vivo. The strongest TNF eliciting and antitumor activity was found in the PH-I Cb fraction which is an acidic polysaccharide or proteoglycan with molecular weight of approximately 5000.
通过静脉注射从太子参根部分离得到的抗肿瘤组分（PH-I A、PH-I B、PH-I C、PH-I Ca、PH-I Cb），可在接种艾氏腹水瘤（EAT）细胞的ICR小鼠血清中诱导产生肿瘤坏死因子（TNF）。在静脉注射PH-I C、PH-I Ca或PH-I Cb后2小时，接种EAT的小鼠腹水中也能检测到TNF。发现给予这些组分后，EAT细胞的增殖受到显著抑制。我们的结果表明，太子参的抗肿瘤活性可能至少部分与其在体内诱导TNF产生的能力有关。在PH-I Cb组分中发现了最强的TNF诱导和抗肿瘤活性，该组分是一种分子量约为5000的酸性多糖或蛋白聚糖。
