Mlinaric-Galinovic G, Chonmaitree T, Cane P A, Pringle C R, Ogra P L
Department of Pediatrics, Children's Hospital, University of Texas Medical Branch, Galveston 77555-0371.
J Med Virol. 1994 Apr;42(4):380-4. doi: 10.1002/jmv.1890420410.
The epidemiological characteristics and relationship between respiratory syncytial virus (RSV) subgroup and virulence during an outbreak of RSV infection occurring in Southeast Texas in the winter season 1991/92 are described. Fifty-two infants and children were diagnosed with RSV infection by rapid viral antigen detection and/or viral isolation. Subgrouping of the isolates was carried out using 11-monoclonal anti-bodies. Ten isolates were found to be subgroup B, and 8 isolates were subgroup A. The subgroup B strains showed 3 different patterns of reaction with monoclonal antibodies; one of these subgroups was examined further by restriction analysis of parts of its nucleocapsid and attachment protein genes. The peak of RSV outbreak was in December 1991. Both subtypes A and B circulated simultaneously in the same territory, and caused lower respiratory tract infections in similar proportions. The more frequent occurrence of the B subgroup and the diversity of its simultaneously circulated RSV strains have made this outbreak unusual.
本文描述了1991/92年冬季在得克萨斯州东南部爆发呼吸道合胞病毒（RSV）感染期间的流行病学特征，以及RSV亚组与毒力之间的关系。通过快速病毒抗原检测和/或病毒分离，确诊了52例婴幼儿RSV感染病例。使用11种单克隆抗体对分离株进行亚组分型。发现10株为B亚组，8株为A亚组。B亚组毒株与单克隆抗体呈现3种不同的反应模式；其中一个亚组通过对其部分核衣壳和附着蛋白基因进行限制性分析作进一步研究。RSV爆发高峰出现在1991年12月。A、B两种亚型在同一地区同时传播，并以相似比例引起下呼吸道感染。B亚组的更频繁出现及其同时传播的RSV毒株的多样性使得此次疫情不同寻常。
