Lukic-Grlic A, Cane P A, Bace A, Pringle C R, Mlinaric-Galinovic G, Popow-Kraupp T
Department of Microbiology, A. Stampar School of Public Health, Medical School, University of Zagreb, Croatia.
Arch Virol. 1998;143(7):1441-7. doi: 10.1007/s007050050388.
Thirty-two RSV strains recovered during the winter months of 1987/88 to 1993/94 from hospitalized children in Vienna, Austria and Zagreb, Croatia were analysed for antigenic and genetic variations. Twenty-nine of the 32 isolates investigated belonged to group A and 3 to group B, with the majority of infections caused by subgroup A1 (21 of 29). Restriction endonuclease mapping of PCR products derived from parts of the N and G gene of 18 group A strains identified 3 distinct lineages, very similar to those defined by analysis of recurrent epidemics in Birmingham, United Kingdom during the same period. Results of this study provide further information on the global pattern of RSV and show that very similar viruses are present simultaneously in widely separated areas.
对1987/88年至1993/94年冬季期间从奥地利维也纳和克罗地亚萨格勒布住院儿童中分离出的32株呼吸道合胞病毒（RSV）进行了抗原性和基因变异分析。在研究的32株分离株中，29株属于A组，3株属于B组，大多数感染由A1亚组引起（29株中的21株）。对18株A组毒株N基因和G基因部分的PCR产物进行限制性内切酶图谱分析，确定了3个不同的谱系，与同期英国伯明翰反复流行情况分析所确定的谱系非常相似。本研究结果为RSV的全球模式提供了进一步信息，并表明在广泛分隔的地区同时存在非常相似的病毒。
