Lukić-Grlić A, Mlinarić-Galinović G
Zavod za mikrobiologiju i parasitologiju, SNZ A. Stampar, Medicinski fakultet, Sveuciliste u Zagrebu.
Lijec Vjesn. 1999 Apr-May;121(4-5):144-7.
Antigenically the respiratory syncytial virus (RSV) is of two types: A and B. Five structural proteins express virus type differences. Antigenic and genetic differences among individual strains of the same virus type are classed accordingly by monoclonal antibody reactivity into antigenic subtypes; for nucleotide sequence and restriction maps of individual gene polymerase chain reaction products they have different genetic categories: SHL 1-6, NP 1-6. Still unproved is the association between the virus-caused clinical picture severity and virus type. One type or both may be the causative agents of an RSV epidemic. Between 1988 and 1994, both types of RSV strains circulated in Central Europe, as well as the different subtypes within each type; type A, particularly subtype A1, was absolutely dominant. RSV isolates were of genotypes SHL 2, SHL 1/3/4, SHL 5, NP 1. They occurred in the same order as the genotypes shown in the rest of Europe and the world.
从抗原性上看，呼吸道合胞病毒（RSV）有两种类型：A 型和 B 型。五种结构蛋白表现出病毒类型差异。同一病毒类型的各个毒株之间的抗原性和基因差异，根据单克隆抗体反应性相应地分为抗原亚型；就单个基因聚合酶链反应产物的核苷酸序列和限制性图谱而言，它们有不同的基因类别：SHL 1 - 6、NP 1 - 6。病毒引起的临床症状严重程度与病毒类型之间的关联仍未得到证实。一种类型或两种类型都可能是 RSV 流行的病原体。1988 年至 1994 年期间，中欧地区 A 型和 B 型 RSV 毒株均有传播，且每种类型内都有不同的亚型；A 型，尤其是 A1 亚型，绝对占主导地位。RSV 分离株的基因型为 SHL 2、SHL 1/3/4、SHL 5、NP 1。它们出现的顺序与欧洲其他地区和世界其他地区所示的基因型顺序相同。
