Weiner I M, Fanelli G M
Nephron. 1975;14(1):33-47. doi: 10.1159/000180434.
Several aspects of the comparative physiology and pharmacology of renal urate handling are considered; with special attention to bidirectional transport, the existence of intrarenal urate synthesis and degradation in certain species, and the nature and sites of the reabsorptive and secretory processes. Interspecies variations in the sensitivity of the kidney to uricosuric agents and the degree of specificity of the secretory mechanism are discussed. A variety of techniques, especially as applied in certain nonhuman primates, have led to a concept of very rapid trans-tubular fluxes of urate--a concept which may apply in man.
本文探讨了肾脏尿酸处理的比较生理学和药理学的几个方面；特别关注双向转运、某些物种肾内尿酸合成与降解的存在情况，以及重吸收和分泌过程的性质与部位。文中还讨论了不同物种肾脏对促尿酸排泄药物敏感性的种间差异以及分泌机制的特异性程度。多种技术，尤其是应用于某些非人灵长类动物的技术，引出了尿酸跨肾小管快速通量的概念——这一概念可能也适用于人类。
