Suzuki E, Arakawa M
Department of Medicine (II), Niigata University School of Medicine.
Nihon Rinsho. 1994 Jun;52(6):1544-9.
The 565 pulmonary tissue specimens taken from 155 sarcoidosis patients by transbronchial lung biopsy (TBLB) were studied by light microscopy. In stage II and III patients, the number of granulomas, the positive rate of hyalinofibrous granuloma, the relative proportion of hyalonofibrous granuloma group, and the degree of perigranulomal fibrosis and granuloma confluence were significantly higher than those in stage 0 and I patients. In stage I patients, the resolution of bilateral hiller lymphadenopathy was significantly more frequent in the atrophic granuloma group than in the hyalinofibrous granuloma group. The pulmonary lesions had a tendency to persist for a long time in stage II and III patients with hyalinofibrous granuloma or granuloma confluence. Newly appearing pulmonary lesions showed hypertrophic granulomas, as well as, marked lymphocytic cuffing. It appears that the changes in the stage on chest X-ray relate, not to the number of granulomas, but to the morphological findings of granulomas.
对155例结节病患者经支气管肺活检（TBLB）获取的565份肺组织标本进行了光镜检查。在Ⅱ期和Ⅲ期患者中，肉芽肿数量、透明纤维性肉芽肿阳性率、透明纤维性肉芽肿组的相对比例以及肉芽肿周围纤维化和肉芽肿融合程度均显著高于0期和Ⅰ期患者。在Ⅰ期患者中，双侧肺门淋巴结病变消退在萎缩性肉芽肿组比透明纤维性肉芽肿组更为常见。在患有透明纤维性肉芽肿或肉芽肿融合的Ⅱ期和Ⅲ期患者中，肺部病变有长期持续的倾向。新出现的肺部病变表现为肥厚性肉芽肿以及明显的淋巴细胞套袖状浸润。胸部X线分期的变化似乎与肉芽肿数量无关，而与肉芽肿的形态学表现有关。
