从艾滋病患者和非艾滋病患者中分离出的鸟分枝杆菌复合群（MAC）菌株的毒力比较。

Comparison of virulence of Mycobacterium avium complex (MAC) strains isolated from AIDS and non-AIDS patients.

作者信息

Reddy V M, Parikh K, Luna-Herrera J, Falkinham J O, Brown S, Gangadharam P R

机构信息

Mycobacteriology Research Laboratories, University of Illinois College of Medicine at Chicago.

出版信息

Microb Pathog. 1994 Feb;16(2):121-30. doi: 10.1006/mpat.1994.1013.

DOI:10.1006/mpat.1994.1013

PMID:8047000

Abstract

Mycobacterium avium complex (MAC) strains from AIDS and non-AIDS patients and from the environment were studied for their colony morphology and virulence in beige mice. The majority of the MAC isolates from AIDS patients, in contrast to those from non-AIDS patients and the environment, showed increased virulence. Similarly, the majority of the MAC isolates from AIDS patients formed smooth transparent (ST) colonies, whereas most of the non-AIDS isolates formed smooth opaque (SO) or intermediate (IM) type of colonies. MAC isolates from the same AIDS patient obtained at different times were found to be heterogenic with respect to serotype, RFLP and glycolipid patterns, suggesting that these patients might be infected with more than one strain of MAC.

摘要

对来自艾滋病患者、非艾滋病患者以及环境中的鸟分枝杆菌复合体（MAC）菌株进行了研究，观察其在米色小鼠中的菌落形态和毒力。与来自非艾滋病患者和环境的MAC分离株相比，大多数来自艾滋病患者的MAC分离株显示出更高的毒力。同样，大多数来自艾滋病患者的MAC分离株形成光滑透明（ST）菌落，而大多数非艾滋病分离株形成光滑不透明（SO）或中间（IM）型菌落。发现在不同时间从同一艾滋病患者获得的MAC分离株在血清型、限制性片段长度多态性（RFLP）和糖脂模式方面具有异质性，这表明这些患者可能感染了不止一种MAC菌株。