Central mediation of tracheal pressure through H1 and H2 receptors after histamine administration to the fourth ventricle of anesthetized rabbit.

Administration of 1.5, 5.0 and 15 nmol histamine (HA) into the fourth ventricle (IVth) decreased tracheal pressure (PT) dose-dependently in anesthetized rabbits. Maximum decrease of PT occurred 0.9 +/- 0.1 min (mean +/- S.E.M., n = 9) after administration of 15 nmol, and recovery occurred at 4.5 +/- 1.0 min (n = 9). The decrease of PT was blocked by the H1 receptor antagonist, pyrilamine administration into the IVth, or intravenous injection of the alpha-adrenoceptor antagonist, phentolamine. Recovery from the PT decrease was delayed by the H2 receptor antagonist, cimetidine. The results suggest that HA centrally decreases PT through H1 receptors, which action is mediated by the sympathetic nervous system, and this decrease may be modulated through H2 receptors.