某些N2-取代噌啉衍生物的合成及其对中枢神经系统的作用
Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives.
作者信息
Stańczak A, Kwapiszewski W, Szadowska A, Pakulska W
机构信息
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Lódź, Poland.
出版信息
Pharmazie. 1994 Jun;49(6):406-12.
PMID:8047541
Abstract
Alkylation of 4-hydroxycinnolines using ethyl bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
摘要
使用溴乙酸乙酯对4-羟基喹啉进行烷基化反应生成了N2-取代的乙酸。这些酸被转化为酯和酰胺。一些得到的酸用锌粉还原得到4-氧代-1,2,3,4-四氢-2-喹啉乙酸。对几种化合物进行了中枢神经系统作用测试。
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