Raoux N, Benoit O, Dantchev N, Denise P, Franc B, Allilaire J F, Widlöcher D
Research Unit 302, Psychopathology and Pharmacology of Behavior, Hôpital de la Salpêtrière, Paris, France.
Psychiatry Res. 1994 Apr;52(1):85-98. doi: 10.1016/0165-1781(94)90122-8.
The 24-hour motor activity pattern was evaluated in 26 inpatients with major depression at treatment onset and after 4 weeks of antidepressant therapy. Clinical state, depression, and psychomotor retardation, as well as motor activity level and circadian rhythm, were simultaneously assessed. Treatment responders and nonresponders were also considered. Diurnal hypoactivity and reduced 24-hour rhythm amplitude were found at treatment onset. Activity level increased significantly on discharge. The rest-activity cycle for each depressed patient fit a cosine function of 24-hour periodicity. Data tended to show no phase shift but a large intragroup phase variability. Preliminary findings of a negative correlation between basic activity level and clinical improvement, and a trend toward responders having a lower activity level than nonresponders, suggest that activity could be used to predict therapeutic response.
对26名重度抑郁症住院患者在治疗开始时及抗抑郁治疗4周后进行了24小时运动活动模式评估。同时评估了临床状态、抑郁情况、精神运动迟缓以及运动活动水平和昼夜节律。还对治疗反应者和无反应者进行了考量。治疗开始时发现日间活动减少和24小时节律幅度降低。出院时活动水平显著增加。每位抑郁症患者的静息-活动周期符合24小时周期性的余弦函数。数据倾向于显示无相位偏移，但组内相位变异性较大。基础活动水平与临床改善之间呈负相关的初步发现，以及反应者活动水平低于无反应者的趋势，表明活动可用于预测治疗反应。
