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[健康成年人的免疫球蛋白水平(G、A和M)]

[Immunoglobulin level (G, A and M) in healthy adults].

作者信息

Malkina L A, Shakhanina K L

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1975 Jan(1):33-7.

PMID:804777
Abstract

The simple radial immunodiffusion method was applied to determination of the quantitative content of three principal classes of immunoglobulins (G, A and M) in 987 blood sera of healthy adults, Moscow residents, aged from 19 to 50 years (donors). Monospecific antisera and standard sera were used. Investigations were carried out in men and women of three age groups: 19--29, 30--39 and 40--50 years old. The mean level of immunoglobulins G, A and M was expressed in International Units (IU/ml) and in milligrams per 100 ml of the serum (mg%). The IgG and the IgM concentration proved to be higher in women than in men in all the age groups (the detected differences were statistically significant); as to the average IgA level no statistically significant differences were revealed either by age or by sex. As a result of these studies mean levels of immunoglobulin G, A and M were determined in the blood sera of adult healthy persons, Moscow residents; which could serve as the basis for comparing the immunoglobulin content under normal conditions and in different pathological conditions of the organism.

摘要

采用简单的单向放射免疫扩散法,对987名年龄在19至50岁的莫斯科成年健康居民(献血者)血清中的三类主要免疫球蛋白(G、A和M)进行定量测定。使用了单特异性抗血清和标准血清。对三个年龄组的男性和女性进行了调查:19 - 29岁、30 - 39岁和40 - 50岁。免疫球蛋白G、A和M的平均水平以国际单位(IU/ml)和每100毫升血清中的毫克数(mg%)表示。在所有年龄组中,女性的IgG和IgM浓度均高于男性(检测到的差异具有统计学意义);至于平均IgA水平,无论是按年龄还是按性别均未发现统计学上的显著差异。通过这些研究,确定了莫斯科成年健康居民血清中免疫球蛋白G、A和M的平均水平;这可为比较机体在正常条件和不同病理条件下的免疫球蛋白含量提供依据。

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