Avruch J, Zhang X F, Kyriakis J M
Diabetes Unit, Massachusetts General Hospital, Boston.
Trends Biochem Sci. 1994 Jul;19(7):279-83. doi: 10.1016/0968-0004(94)90005-1.
The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.
Ras癌蛋白是一种GTP激活的分子开关，它直接与Raf癌蛋白相互作用，以募集丝裂原活化蛋白激酶及其下游分子。通过这种方式，由酪氨酸激酶启动的促有丝分裂信号被Ras转化为丝氨酸和苏氨酸残基上的调节性磷酸化波，根据其强度、持续时间以及可用底物的种类，该磷酸化波会导致细胞分化或细胞分裂。
