细胞因子与生殖
Cytokines and reproduction.
作者信息
Simón C, Polan M L
机构信息
Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305-5317.
出版信息
West J Med. 1994 May;160(5):425-9.
Cytokines are important in reproduction. Interleukin-1, an established immune mediator, is one of the best-characterized members of the cytokine family. We describe what is known about the interactions between the interleukin-1 system and the hypothalamic-pituitary-gonadal, the hypothalamic pituitary-adrenal, and the hypothalamic-pituitary-thyroid axes. We also review the ovarian role of the interleukin-1 system. This cytokine has an immense and, as yet, imperfectly understood effect on the human reproductive tract. Clearly the immune system has a potential autocrine, paracrine, and endocrine role in regulating human reproductive events such as ovulation, luteinization, and implantation.
细胞因子在生殖过程中起着重要作用。白细胞介素-1作为一种公认的免疫介质，是细胞因子家族中特征最为明确的成员之一。我们阐述了白细胞介素-1系统与下丘脑-垂体-性腺轴、下丘脑-垂体-肾上腺轴以及下丘脑-垂体-甲状腺轴之间相互作用的已知情况。我们还综述了白细胞介素-1系统在卵巢中的作用。这种细胞因子对人类生殖道有着巨大且尚未被完全理解的影响。显然，免疫系统在调节诸如排卵、黄体化和着床等人类生殖事件中具有潜在的自分泌、旁分泌和内分泌作用。
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