人类卵巢中的细胞因子：存在于卵泡液中及其与白三烯B4的相关性。
Cytokines in the human ovary: presence in follicular fluid and correlation with leukotriene B4.
作者信息
Bili H, Tarlatzis B C, Daniilidis M, Fleva A, Bontis J, Tourkantonis A, Mantalenakis S
机构信息
First Department of Obstetrics & Gynecology, Aristotle University, Thessaloniki, Greece.
出版信息
J Assist Reprod Genet. 1998 Feb;15(2):93-8. doi: 10.1007/BF02766833.
PURPOSE
This study was undertaken to correlate the follicular levels of interleukin (IL)-1 alpha, IL-2, tumor necrosis factor-alpha (TNF-alpha), and leukotriene (LT) B4 with oocyte maturity, fertilization, and achievement of pregnancy.
METHODS
The material was obtained from 22 women undergoing IVF, 8 of whom became pregnant and 14 of whom did not.
RESULTS
All of the studied cytokines and LT B4 were found in follicular fluids, but there were no significant differences according to oocyte maturity, fertilization, embryo quality, and achievement of pregnancy. On the other hand, a significant positive correlation was found between IL-1 alpha and TNF-alpha, IL-1 alpha, and LT B4 as well as between TNF-alpha and LT B4 in follicular fluids with subsequently fertilized oocytes.
CONCLUSIONS
It seems that IL-1 alpha, TNF-alpha and LT B4 may take part in the process of follicle wall degradation, and their follicular correlations may suggest more optimal follicular and oocyte development and maturation.
目的
本研究旨在探讨白细胞介素（IL）-1α、IL-2、肿瘤坏死因子-α（TNF-α）和白三烯（LT）B4的卵泡水平与卵母细胞成熟、受精及妊娠结局之间的相关性。
方法
研究材料取自22例行体外受精（IVF）的女性，其中8例成功妊娠，14例未妊娠。
结果
所有研究的细胞因子和LT B4均在卵泡液中被检测到，但在卵母细胞成熟度、受精情况、胚胎质量及妊娠结局方面未发现显著差异。另一方面，在随后受精的卵母细胞的卵泡液中，发现IL-1α与TNF-α、IL-1α与LT B4以及TNF-α与LT B4之间存在显著正相关。
结论
IL-1α、TNF-α和LT B4似乎参与了卵泡壁降解过程，它们在卵泡内的相关性可能提示卵泡和卵母细胞的发育及成熟更为理想。
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