Okuda B
Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.
Acta Physiol Scand. 1994 May;151(1):1-6. doi: 10.1111/j.1748-1716.1994.tb09715.x.
To elucidate the role of the cerebellar dentate nucleus in oculomotor system, we investigated the dentato-cerebral projection onto the frontal cortex around the fundus of the presylvian sulcus corresponding to a subregion of the frontal eye field (FEF) in the cat. Stimulation of the dentate nucleus induced laminar field potentials consisting of mainly a surface positive-depth negative wave and a subsequent depth positive wave with or without a surface negative wave in the contralateral FEF. Thalamic relay neurones, identified by collision test, were mainly distributed in the dorsal part of the ventromedial (VM) nucleus. Injection of wheat germ agglutinin conjugated horseradish peroxidase into the thalamic VM nucleus anterogradely labelled afferent terminals in layers I and III of the FEF and retrogradely labelled somata of cerebello-thalamic neurones in the contralateral dentate nucleus. Both electrophysiological and morphological results consistently revealed cerebello-thalamo-cerebral projection onto the FEF which may be implicated in eye-limb coordination control.
为阐明小脑齿状核在动眼系统中的作用，我们研究了猫的齿状核向额叶前沟底部周围额叶皮质的投射，该区域对应于额叶眼区（FEF）的一个子区域。刺激齿状核在对侧FEF诱发了层状场电位，主要由一个表面正波-深度负波以及随后的深度正波组成，有或没有表面负波。通过碰撞试验鉴定的丘脑中继神经元主要分布在腹内侧（VM）核的背侧部分。将结合辣根过氧化物酶的小麦胚凝集素注入丘脑VM核，顺行标记FEF第I层和第III层的传入终末，并逆行标记对侧齿状核中小脑-丘脑神经元的胞体。电生理和形态学结果均一致显示了小脑-丘脑-大脑向FEF的投射，这可能与眼-肢体协调控制有关。
