Kyuhou S, Kawaguchi S
J Comp Neurol. 1987 May 22;259(4):571-90. doi: 10.1002/cne.902590407.
The fastigiocerebral projection in the cat was investigated electrophysiologically by recording field potentials and unit activities and also morphologically by anterograde and retrograde HRP methods. Three cortical areas mostly hidden in sulci, two in the frontal cortex and one in the insular cortex, were responsive to fastigial stimulation under pentobarbital anesthesia. The responsive areas in the frontal cortex were the ventral bank of the cruciate sulcus and the area surrounding the fundus of the presylvian sulcus; the latter area corresponds to a subregion of the frontal eye field. The responsive area in the insular cortex was the ventral bank of the anterior ectosylvian sulcus, which overlaps largely with the "anterior ectosylvian visual area." The response in the frontal cortex was a surface-positive, depth-negative wave, whereas the response in the insular cortex was a surface-negative, depth-positive wave. Anterogradely labeled terminals of the fastigiothalamic projection were most dense in the ventromedial (VM) nucleus in which retrogradely labeled neurons were numerous when WGA-HRP was injected into any one of the three cortical areas. In agreement with the results of the HRP studies, units that responded orthodromically to fastigial stimulation and antidromically to cortical stimulation were located in the thalamic VM nucleus. There was a marked difference between the frontal and insular cortices in laminar distribution of terminals of the thalamocortical projection fibers. Anterogradely labeled terminals after injection of WGA-HRP into the VM nucleus were distributed mainly in layers I and III in the frontal cortex, whereas they were distributed mainly in layer I in the insular cortex.
通过记录场电位和单位活动，用电生理学方法对猫的顶核-脑投射进行了研究，并采用顺行和逆行HRP法进行了形态学研究。在戊巴比妥麻醉下，三个主要隐藏在脑沟中的皮质区域对顶核刺激有反应，其中两个位于额叶皮质，一个位于岛叶皮质。额叶皮质的反应区域是十字沟的腹侧缘和前薛氏沟底部周围的区域；后一区域对应于额叶眼区的一个亚区。岛叶皮质的反应区域是外侧薛氏前沟的腹侧缘，它与“外侧薛氏前视觉区”大部分重叠。额叶皮质的反应是表面阳性、深度阴性波，而岛叶皮质的反应是表面阴性、深度阳性波。顶核-丘脑投射的顺行标记终末在腹内侧（VM）核中最为密集，当将WGA-HRP注入三个皮质区域中的任何一个时，该核中有大量逆行标记的神经元。与HRP研究结果一致，对顶核刺激产生顺向反应且对皮质刺激产生逆向反应的单位位于丘脑VM核中。丘脑皮质投射纤维终末的层状分布在额叶皮质和岛叶皮质之间存在明显差异。将WGA-HRP注入VM核后，顺行标记的终末主要分布在额叶皮质的I层和III层，而在岛叶皮质中主要分布在I层。
