Blomqvist G, Seitz R J, Sjögren I, Halldin C, Stone-Elander S, Widén L, Solin O, Haaparanta M
Department of Clinical Neuroscience, Karolinska Hospital, Stockholm.
Acta Physiol Scand. 1994 May;151(1):29-43. doi: 10.1111/j.1748-1716.1994.tb09718.x.
The relationship between regional oxidative and total rCMRglc in five healthy volunteers in activated and non-activated areas of the brain has been investigated with positron emission tomography (PET). The tracers [1-11C]-D-glucose and [2-18F]2-fluoro-2-deoxy-D-glucose were used. A previous study has shown that the former may be used to measure the rate of glucose oxidation while the latter tracer is used to measure the total rate of glucose consumption. Regional activation was performed (voluntary finger movements). Use of a computerized brain atlas enabled comparison between the regional oxidative and total rCMRglc in each volume element of the brain for the group of subjects. The values of total and oxidative rCMRglc, when calculated for each volume element of the brain and displayed in a scatter plot, were found to be symmetrically grouped around a straight line which passes close to the origin. The slope of this line varied between the subjects. This indicates that, on the average, the fraction of non-oxidative glucose utilization is constant within each subject, regardless of the value of rCMRglc and, further, that the fraction of non-oxidative glucose utilization varies between subjects. The total and oxidative CMRglc in the activated left hand area were 23.4 +/- 0.9% (mean +/- SEM) and 11.7 +/- 0.3%, respectively, higher than in the contralateral homologous non-activated area. Our interpretation of the difference is that regional activation increases the fraction of non-oxidative glucose consumption. This interpretation is supported by a previous PET study using [15O]O2, and by studies using MRS technique.
利用正电子发射断层扫描（PET）研究了5名健康志愿者大脑激活区和非激活区局部氧化型与总rCMRglc之间的关系。使用了示踪剂[1-11C]-D-葡萄糖和[2-18F]2-氟-2-脱氧-D-葡萄糖。先前的一项研究表明，前者可用于测量葡萄糖氧化速率，而后者用于测量葡萄糖消耗的总速率。进行了局部激活（自主手指运动）。使用计算机化脑图谱能够比较该组受试者大脑每个体素中的局部氧化型与总rCMRglc。当计算大脑每个体素的总rCMRglc和氧化型rCMRglc值并显示在散点图中时，发现它们围绕一条接近原点的直线对称分布。这条线的斜率在受试者之间有所不同。这表明，平均而言，每个受试者体内非氧化型葡萄糖利用的比例是恒定的，与rCMRglc的值无关，而且，非氧化型葡萄糖利用的比例在受试者之间存在差异。激活的左手区域的总CMRglc和氧化型CMRglc分别比同侧同源非激活区域高23.4 +/- 0.9%（平均值 +/- 标准误）和11.7 +/- 0.3%。我们对这种差异的解释是，局部激活增加了非氧化型葡萄糖消耗的比例。这一解释得到了先前一项使用[15O]O2的PET研究以及使用MRS技术的研究的支持。
