Van Doorne L, Soubry R, Wackens G, Goossens A
Dienst Stomatologie en maxillo-faciale heelkunde, AZ-V.U.B., Diensthoofd.
Acta Stomatol Belg. 1994 Mar;91(1):49-54.
This report deals with a case of atypical histiocytic granuloma in a male patient of 65 years old. The white ulcerative lesion was located in the upper labial mucosa. No bleeding or pain was observed on palpation. A complete spontaneous healing was observed within two weeks. On histologic examination an excess of atypical cells with multiple mitotic configurations was seen. These cells were histiocytes (this was substantiated by the use of a specific histochemical colour method (KP1-CD 68)). The authors emphasize the difficult clinical differential diagnosis with a traumatic eosinophilic granuloma. Also the other ulcerative lesions, including spinocellular epithelioma, of the oral mucosa must be considered. Only biopsy will differentiate between these entities.
本报告涉及一名65岁男性患者的非典型组织细胞性肉芽肿病例。白色溃疡性病变位于上唇黏膜。触诊时未观察到出血或疼痛。两周内观察到完全自发愈合。组织学检查可见大量具有多种有丝分裂形态的非典型细胞。这些细胞为组织细胞（通过使用特定的组织化学染色方法（KP1-CD 68）得以证实）。作者强调与创伤性嗜酸性肉芽肿进行临床鉴别诊断存在困难。还必须考虑口腔黏膜的其他溃疡性病变，包括棘细胞上皮瘤。只有活检才能区分这些病变。
