Rigaud D, Betoulle D, Chauvel A, Alberto L A, Apfelbaum M
Unité de Recherches en Nutrition Humaine, Institut National de la Santé et de la Recherche Médicale U. 286, Faculté Xavier Bichat, Paris, France.
Am J Physiol. 1994 Jul;267(1 Pt 2):R150-5. doi: 10.1152/ajpregu.1994.267.1.R150.
Food intake depends on the palatability of the diet and on the energy delivered to the body. It is not known, however, whether the palatability of a diet is able to modulate the inhibitory effect of energy input on food intake. To address this question, we have measured intake during sham feeding for diets of different palatabilities in rats receiving varying levels of duodenal energy load. Rats were offered sucrose solutions (6, 10, or 30%) or mixed liquid diets without or with physiological duodenal energy loads using a mixed liquid diet. Compared with that seen during real feeding, meal size during sham feeding was increased for palatable diets but not for less palatable diets. Intraduodenal infusion of the mixed liquid diet inhibited the intake of all diets given by sham feeding. This inhibition was dependent on the level of duodenal energy load and was significantly greater for more palatable diets than for less palatable ones. We conclude that the inhibitory effects of intestinal nutrient load on intake are significant for all diets but have a more pronounced effect on the intake of highly palatable diets.
食物摄入量取决于饮食的适口性以及输送到身体的能量。然而，目前尚不清楚饮食的适口性是否能够调节能量输入对食物摄入量的抑制作用。为了解决这个问题，我们测量了接受不同十二指肠能量负荷水平的大鼠在假饲期间对不同适口性饮食的摄入量。使用混合液体饮食，给大鼠提供蔗糖溶液（6%、10%或30%）或有无生理性十二指肠能量负荷的混合液体饮食。与实际进食时相比，假饲期间适口性饮食的餐量增加，而适口性较差的饮食则没有增加。十二指肠内注入混合液体饮食抑制了假饲给予的所有饮食的摄入量。这种抑制作用取决于十二指肠能量负荷水平，并且对于适口性较好的饮食比适口性较差的饮食更为显著。我们得出结论，肠道营养负荷对摄入量的抑制作用对所有饮食都很显著，但对高适口性饮食的摄入量影响更为明显。
