5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮的O-（2-二烷基氨基乙基）肟类化合物，具有降压、抗心律失常及其他活性。

O-(2-dialkylaminoethyl)oximes of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo [2.2.2]octan-6-ones with hypotensive, antiarrhythmic and other activities.

作者信息

Mariani E, Bargagna A, Longobardi M, Schenone P, D'Amico M, Filippelli W, Falciani M, Filippelli A

机构信息

Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.

出版信息

Farmaco. 1994 Apr;49(4):267-70.

Abstract

The synthesis of some O-(2-dialkylaminoethyl)oximes of 5-[(4-methoxy- or 4-methylthiophenyl)methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2] octan-6-ones 5 by reaction of the corresponding oximes as sodium salts with the appropriate 2-chloroethyldialkylamine in dry ethanol solution is described. Some aminoethers 5 showed appreciable hypotensive and antiarrhythmic activities in rats, as well as a weak platelet antiaggregating activity in vitro and a moderate infiltration anesthesia in mice.

摘要

描述了通过相应的肟钠盐与适当的2-氯乙基二烷基胺在干燥乙醇溶液中反应合成5-[(4-甲氧基或4-甲基硫代苯基)亚甲基]-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮5的一些O-(2-二烷基氨基乙基)肟。一些氨基醚5在大鼠中显示出明显的降压和抗心律失常活性，以及在体外有较弱的血小板抗聚集活性和在小鼠中有适度的浸润麻醉作用。

相似文献

1

O-(2-dialkylaminoethyl)oximes of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo [2.2.2]octan-6-ones with hypotensive, antiarrhythmic and other activities.5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮的O-（2-二烷基氨基乙基）肟类化合物，具有降压、抗心律失常及其他活性。

Farmaco. 1994 Apr;49(4):267-70.

2

N-substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo [2.2.2]-octan-6-ones with platelet antiaggregating and local anesthetic activities.1,3,3-三甲基-5-内-(1-哌啶基或4-吗啉基)-2-氧杂双环[2.2.2]辛烷-6-酮的N-取代O-(3-氨基-2-羟丙基)肟，具有血小板抗聚集和局部麻醉活性。

Farmaco. 1992 Oct;47(10):1249-62.

3

5-[[omega-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2- oxabicyclo [2.2.2.]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities.具有降压、局部麻醉、抗心律失常及其他活性的5-[[ω-(二烷基氨基)烷氧基]亚甲基]-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮

Farmaco. 1994 Sep;49(9):541-4.

4

5-[4-(omega-dialkylaminoalkoxy)phenylmethylene] -1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and other activities.具有血小板抗聚集及其他活性的5-[4-(ω-二烷基氨基烷氧基)苯亚甲基]-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-酮

Farmaco. 1991 May;46(5):657-68.

5

omega-Dialkylaminoalkyl ethers of 5-(arylmethylene)-1,3,3-trimethyl-2- oxabicyclo[2.2.2]octan-6-hydroxyimines with platelet antiaggregating and other activities.5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的ω-二烷基氨基烷基醚，具有抗血小板聚集及其他活性。

Farmaco. 1991 Jan;46(1):85-98.

6

2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities.具有抗心律失常和局部麻醉活性的2-芳基-3-苯基氨基-4,5-二氢-2H-苯并[g]吲唑

Farmaco. 1995 Mar;50(3):179-82.

7

3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities.具有解热、镇痛、抗心律失常、降压及其他活性的3-（芳基氨基）-6,7-二氢-6-甲基吡喃并[4,3-c]吡唑-4（1H或2H）-酮

Farmaco. 1993 Dec;48(12):1697-708.

8

Aminoethers of 1,3,3-trimethyl-5-(phenylmethylene)-2-oxabicyclo[2.2.2]octan-6-h ydroxy imine with antiarrhythmic activity.具有抗心律失常活性的1,3,3-三甲基-5-(苯亚甲基)-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的氨基醚

Farmaco Sci. 1988 Nov;43(11):879-86.

9

O-[omega-(Dialkylamino)alkyl]oximes of (+)-1,7,7-trimethylbicyclo [2.2.1]heptan-2-one with hypotensive, antiinflammatory, analgesic, local anesthetic and other activities.（+）-1,7,7-三甲基双环[2.2.1]庚-2-酮的O-[ω-（二烷基氨基）烷基]肟类化合物，具有降压、抗炎、镇痛、局部麻醉及其他活性。

Farmaco. 1994 Sep;49(9):545-50.

10

omega-Dialkylaminoalkyl ethers of 5-endo-dialkylamino-1,3,3-trimethyl-2-oxabicyclo [2.2.2]octan-6-hydroxyimines with platelet antiaggregating, antiarrhythmic and local anesthetic activities.5-内-二烷基氨基-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基胺的ω-二烷基氨基烷基醚，具有血小板抗聚集、抗心律失常和局部麻醉活性。

Farmaco. 1990 Sep;45(9):1013-25.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验