Schenone S, Bruno O, Ranise A, Bondavalli F, D'Amico M, Filippelli W, Falcone G, De Novellis V
Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
Farmaco. 1995 Mar;50(3):179-82.
The synthesis of novel 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles 4a-f, starting from N-phenyl-3,4-dihydro-1(2H)-oxonaphthalene-2-carbothioamide and the proper arylhydrazines, is described. Title compounds were evaluated for antiinflammatory, analgesic, antipyretic, antiarrhythmic, hypotensive, local anaesthetic and platelet antiaggregating activities; some of them showed an appreciable antiarrhythmic activity in rats and a good level of infiltration anaesthesia in mice.
描述了从N-苯基-3,4-二氢-1(2H)-氧代萘-2-硫代甲酰胺和适当的芳基肼出发合成新型2-芳基-3-苯基氨基-4,5-二氢-2H-苯并[g]吲唑4a-f的方法。对标题化合物进行了抗炎、镇痛、解热、抗心律失常、降压、局部麻醉和血小板抗聚集活性的评估；其中一些在大鼠中显示出明显的抗心律失常活性，在小鼠中表现出良好的浸润麻醉水平。
