Pedini M, Alunni Bistocchi G, Ricci A, Bastianini L, Lepri E
Istituto di Biochimica e Chimica Medica, Facoltà di Medicina e Chirurgia, Università degli Studi di Perugia, Italia.
Farmaco. 1994 Dec;49(12):823-7.
Over the last decade, several derivatives of benzimidazole have been synthesized; some of them turned out to have a good antimicrobial activity; however, all of them were not soluble in water. Therefore the N1-heterosides of four derivatives of 2-(2'-furyl) benzimidazole, chosen from those with the highest biological activity have been now synthesized. These compounds were expected to have some new properties, including a good water-solubility and a higher or at least similar biological activity; furthermore, taking into account some previously published data on similar molecules, an antileukemic activity was expected. However, no one of these hypothesis was confirmed experimentally.
在过去十年中，已经合成了几种苯并咪唑衍生物；其中一些被证明具有良好的抗菌活性；然而，它们都不溶于水。因此，现在已经合成了从具有最高生物活性的化合物中挑选出的2-(2'-呋喃基)苯并咪唑四种衍生物的N1-杂糖苷。预计这些化合物会有一些新特性，包括良好的水溶性和更高或至少相似的生物活性；此外，考虑到之前发表的关于类似分子的一些数据，预计它们具有抗白血病活性。然而，这些假设均未得到实验证实。
