Barlet J P, Coxam V, Davicco M J, Gaumet N
INRA-Theix, métabolisme minéral et ostéogénèse, croissance et métabolismes des herbivores, Saint-Genès-Champanelle, France.
Reprod Nutr Dev. 1994;34(3):221-36.
Osteoporosis is a disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to enhanced bone fragility, and a consequent increase in fracture risk. In humans estrogen deficiency following menopause is associated with a more or less intense osteopenia. In some subjects, such a decrease in bone mass induces osteoporosis. Several animal models (ovariectomized female dogs, pigs and monkeys) are used to study the etiology, prophylaxis and treatment for osteoporosis. Nevertheless, the changes in bone metabolism following estrogen deficiency are very similar in rats and humans. Thus, the ovariectomized rat is the most frequently used model for such studies.
骨质疏松症是一种以骨量低、骨组织微结构退化导致骨脆性增加以及骨折风险随之增加为特征的疾病。在人类中，绝经后雌激素缺乏与或多或少明显的骨质减少有关。在一些受试者中，这种骨量减少会诱发骨质疏松症。几种动物模型（去卵巢的雌性犬、猪和猴）被用于研究骨质疏松症的病因、预防和治疗。然而，雌激素缺乏后骨代谢的变化在大鼠和人类中非常相似。因此，去卵巢大鼠是此类研究中最常用的模型。
