Walker M D, Williams D R
Bioinorg Chem. 1975 Jan;4(2):117-24. doi: 10.1016/s0006-3061(00)81020-0.
A model reaction for investigating the effects of chemical parameters on circadian rhythms is suggested. Its main advantage is that oscillations occur on a minute scale rather than daily and so accelerate studies. Some factors were found to increase the period of amplitude of the oscillations, others decreased them. The chemical principles prevailing during such oscillations are itemized. The effects of adding poisons or drugs are also noted and a computer calculation has been used to show that desferrioxamine B treatment for serum iron removal could be 65 percent more effective if administered at the correct point in the circadian cycle.
提出了一种用于研究化学参数对昼夜节律影响的模型反应。其主要优点是振荡发生在分钟尺度而非每日尺度上，从而加速了研究。发现一些因素会增加振荡的周期或幅度，另一些因素则会使其降低。列举了此类振荡过程中占主导地位的化学原理。还指出了添加毒物或药物的影响，并通过计算机计算表明，如果在昼夜周期的正确时间点给予去铁胺B以去除血清铁，其效果可能会提高65%。
