Wilson C L, Wojnarowska F, Dean D, Pasricha J S
Department of Dermatology, Churchill Hospital, Oxford, UK.
Clin Exp Dermatol. 1993 May;18(3):226-30. doi: 10.1111/j.1365-2230.1993.tb02175.x.
The autoimmune blistering disease pemphigus is more common in the Indian subcontinent than in the UK. This study of 19 patients from Oxford, UK and 39 patients from New Delhi, India demonstrates that the incidence of the disease subtypes is different in the two countries. In the UK the commonest subtypes are pemphigus vulgaris and foliaceus with equal prevalence (both eight of 19), but in India pemphigus vulgaris is the most frequent (31 of 39), while pemphigus foliaceus is uncommon (three of 39) and with equal prevalence to the other subtypes. These populations also differ with a younger age at onset in the Indian patients (36.9 India; 52.7 UK) though the sex distribution is the same. Study of the immunopathology shows that the antibodies produced by patients in the two countries do not differ significantly, and are predominantly of the IgG4 subclass. The antibody produced does not vary with the subtype of pemphigus or the age or sex of the patient. Although there are considerable differences between the two groups of patients this difference is not reflected by the subclass of auto-antibody response.
自身免疫性水疱病天疱疮在印度次大陆比在英国更为常见。这项针对来自英国牛津的19名患者和来自印度新德里的39名患者的研究表明，两国疾病亚型的发病率有所不同。在英国，最常见的亚型是寻常型天疱疮和落叶型天疱疮，患病率相同（19例中均为8例），但在印度，寻常型天疱疮最为常见（39例中有31例），而落叶型天疱疮并不常见（39例中有3例），且与其他亚型患病率相同。这些人群也存在差异，印度患者发病年龄更年轻（印度为36.9岁；英国为52.7岁），不过性别分布相同。免疫病理学研究表明，两国患者产生的抗体没有显著差异，且主要为IgG4亚类。产生的抗体不会因天疱疮的亚型或患者的年龄及性别而有所不同。尽管两组患者之间存在相当大的差异，但这种差异并未体现在自身抗体反应的亚类上。
