Shirahama S, Yagi H, Furukawa F, Takigawa M
Department of Dermatology, Hamamatsu University School of Medicine, Japan.
Dermatology. 1994;189 Suppl 1:95-6. doi: 10.1159/000246941.
We report a case of bullous systemic lupus erythematosus (SLE). The patient suddenly presented with a widespread blistering eruption on the trunk and neck during the course of treatment of SLE. A skin biopsy specimen showed subepidermal blisters, and direct immunofluorescence (IF) revealed deposition of IgA, IgG and IgM at the dermoepidermal junction. Indirect IF showed linear IgG deposition along the base of 1 M NaCl-split skin. Rapid resolution of the blisters occurred following treatment with dapsone 50 mg daily.
我们报告一例大疱性系统性红斑狼疮（SLE）。该患者在SLE治疗过程中突然在躯干和颈部出现广泛的水疱性皮疹。皮肤活检标本显示表皮下水疱，直接免疫荧光（IF）显示在真皮表皮交界处有IgA、IgG和IgM沉积。间接IF显示沿1M NaCl分离皮肤底部有线性IgG沉积。每日服用50mg氨苯砜治疗后水疱迅速消退。
